FGF1

FGF1
Dostupne strukture PDB Pretraga ortologa: PDBe RCSB Spisak PDB ID kodova 4QO3, 1AXM, 1DJS, 1DZC, 1DZD, 1E0O, 1EVT, 1HKN, 1JQZ, 1JT3, 1JT4, 1JT5, 1JT7, 1JTC, 1JY0, 1K5U, 1K5V, 1M16, 1NZK, 1P63, 1PZZ, 1Q03, 1Q04, 1RG8, 1RML, 1RY7, 1YTO, 1Z2V, 1Z4S, 2AFG, 2AQZ, 2AXM, 2ERM, 2HW9, 2HWA, 2HWM, 2HZ9, 2K43, 2K4A, 2K8R, 2KI4, 2KI6, 2NTD, 2Q9X, 2RQ9, 3B9U, 3BA4, 3BA5, 3BA7, 3BAD, 3BAG, 3BAH, 3BAO, 3BAQ, 3BAU, 3BAV, 3BB2, 3CQA, 3CRG, 3CRH, 3CRI, 3CU1, 3FGM, 3FJ8, 3FJ9, 3FJA, 3FJB, 3FJC, 3FJD, 3FJE, 3FJF, 3FJH, 3FJI, 3FJJ, 3FJK, 3HOM, 3JUT, 3K1X, 3O3Q, 3OJ2, 3OJM, 3OJV, 3UD7, 3UD8, 3UD9, 3UDA, 4J23, 4Q91, 4Q9G, 4Q9P, 4QAL, 4QBC, 4QBV, 4QC4, 4XKI, 4YOL
Identifikatori
Aliasi	FGF1
Vanjski ID-jevi	OMIM: 131220 MGI: 95515 HomoloGene: 625 GeneCards: FGF1
Lokacija gena (čovjek) Hrom. Hromosom 5 (čovjek)[1] Bend 5q31.3 Početak 142,592,178 bp[1] Kraj 142,698,070 bp[1]
Lokacija gena (miš) Hrom. Hromosom 18 (miš)[2] Bend 18 B3|18 20.74 cM Početak 38,971,726 bp[2] Kraj 39,062,525 bp[2]
Obrazac RNK ekspresije Više referentnih podataka o ekspresiji
Ontologija gena Molekularna funkcija • S100 protein binding • GO:0001948, GO:0016582 vezivanje za proteine • growth factor activity • protein tyrosine kinase activity • phosphatidylinositol-4,5-bisphosphate 3-kinase activity • fibroblast growth factor receptor binding • integrin binding • 1-phosphatidylinositol-3-kinase activity • heparin binding • Hsp70 protein binding Ćelijska komponenta • citoplazma • citosol • extracellular region • cell cortex • Jedarce • jedro • Vanćelijsko • GO:0005578 Vanćelijski matriks Biološki proces • Ćelijska diferencijacija • cellular response to heat • positive regulation of protein phosphorylation • positive regulation of MAP kinase activity • organ induction • lung development • positive regulation of epithelial cell proliferation • anatomical structure morphogenesis • GO:0010740 positive regulation of intracellular signal transduction • branch elongation involved in ureteric bud branching • positive regulation of angiogenesis • MAPK cascade • multicellular organism development • mesonephric epithelium development • Angiogeneza • regulation of endothelial cell chemotaxis to fibroblast growth factor • positive regulation of cholesterol biosynthetic process • Ćelijska proliferacija • positive regulation of cell division • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • GO:0072468 Transdukcija signala • phosphatidylinositol phosphate biosynthetic process • peptidyl-tyrosine phosphorylation • positive regulation of sprouting angiogenesis • fibroblast growth factor receptor signaling pathway • positive regulation of cell population proliferation • phosphatidylinositol-3-phosphate biosynthetic process • regulation of endothelial tube morphogenesis • positive regulation of cell migration • positive regulation of endothelial cell migration • activation of protein kinase B activity • regulation of signaling receptor activity • positive regulation of protein kinase B signaling Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	2246	14164
Ensembl	ENSG00000113578	ENSMUSG00000036585
UniProt	P05230	P61148
RefSeq (mRNK)	NM_000800 NM_001144892 NM_001144934 NM_001144935 NM_001257205 NM_001257206 NM_001257207 NM_001257208 NM_001257209 NM_001257210 NM_001257211 NM_001257212 NM_033136 NM_033137 NM_001354955 NM_001354956 NM_001354957 NM_001354958 NM_001354959 NM_001354961 NM_001354963 NM_001354964 NM_001354951 NM_001354952 NM_001354953 NM_001354954 NM_001354962	NM_010197
RefSeq (bjelančevina)	NP_000791 NP_001138364 NP_001138406 NP_001138407 NP_001244134 NP_001244135 NP_001244136 NP_001244137 NP_001244138 NP_001244139 NP_001244140 NP_001244141 NP_149127 NP_149128 NP_001341884 NP_001341885 NP_001341886 NP_001341887 NP_001341888 NP_001341890 NP_001341892 NP_001341893 NP_001341880 NP_001341881 NP_001341882 NP_001341883 NP_001341891	NP_034327
Lokacija (UCSC)	Chr 5: 142.59 – 142.7 Mb	Chr 18: 38.97 – 39.06 Mb
PubMed pretraga	[3]	[4]
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

FGF1, znan i kao kiseli faktor rasta fibroblasta (aFGF), jest faktor rasta i signalni protein koji je kod ljudi kodiran genom FGF1 sa hromosoma 5.^[5][6]

Sintetizira se kao polipeptid od 155 aminokiselina, čiji je zreli oblik neglikoziliran protein od 17-18 kDa. Protein faktora rasta fibroblasta je prvi put prečišćen 1975. godine, ali su ubrzo nakon toga drugi, koristeći različite uvjete, izolirali kiseli FGF, faktor rasta koji veže heparin-1 i faktor rasta endotelnih ćelija-1.^[7] Sekvenciranje gena otkrilo je da je ova grupa zapravo isti faktor rasta i da je FGF1 bio član proteina porodice FGF.

1. ^ ^{a b c} GRCh38: Ensembl release 89: ENSG00000113578 - Ensembl, maj 2017
2. ^ ^{a b c} GRCm38: Ensembl release 89: ENSMUSG00000036585 - Ensembl, maj 2017
3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ Dionne CA, Crumley G, Bellot F, Kaplow JM, Searfoss G, Ruta M, Burgess WH, Jaye M, Schlessinger J (septembar 1990). "Cloning and expression of two distinct high-affinity receptors cross-reacting with acidic and basic fibroblast growth factors". The EMBO Journal. 9 (9): 2685–92. doi:10.1002/j.1460-2075.1990.tb07454.x. PMC 551973. PMID 1697263.
6. ^ Jaye M, Howk R, Burgess W, Ricca GA, Chiu IM, Ravera MW, O'Brien SJ, Modi WS, Maciag T, Drohan WN (august 1986). "Human endothelial cell growth factor: cloning, nucleotide sequence, and chromosome localization". Science. 233 (4763): 541–5. Bibcode:1986Sci...233..541J. doi:10.1126/science.3523756. PMID 3523756.
7. ^ Burgess WH, Maciag T (1989). "The heparin-binding (fibroblast) growth factor family of proteins". Annual Review of Biochemistry. 58: 575–606. doi:10.1146/annurev.bi.58.070189.003043. PMID 2549857.